OUR VISION
TToP aims at
improving the effectiveness of preclinical prediction
of human responses to drugs reducing costly failures in clinical trials and minimizing the controversial use of animal models.
OUR
VALUES
Equality
Animal-free
Sustainability
THE
TEAM
LORENZO COPPADORO
cO-fOUNDER & CEO
is a Biomedical Engineering PhD student at Politecnico di Milano. He is expert in rapid prototyping techniques, and he is also interested in the startup environment. He attended the Startup Program of the MIP University, and he will hold the CEO role in the early phase of the start-up.
MARIA LOMBARDI
cO-fOUNDER & CTO
is an 8 years’ experience medical biotechnologist. Her expertise concerns cell and tissue cultures and molecular biology. She is fascinated in the development of new technologies approach for patho-physiological studies. She will hold the CTO role in the early phase of the start-up.
THE BOARD OF SCIENTIFIC ADVISORS IS COMPOSED BY:
Gianfranco Beniamino Fiore
scientific advisor
is an associate professor at Politecnico di Milano, holding courses related to cardiovascular biomechanics and technologies for regenerative medicine. He is author of >110 scientific papers in international journals.
monica soncini
scientific advisor
is an associate professor at Politecnico di Milano, holding the course of Cell Bioengineering. She is author of about 70 scientific papers, and she owns 4 patents related to biomedical technologies.
Chiara Foglieni
scientific advisor
is a senior scientist at the Myocardial Disease and Atherosclerosis Unit at San Raffaele scientific institute. She is an expert of 2D/3D models for vascular tissue culture and cell biology, techniques for histology, confocal/electron microscopy, for protein biochemistry and molecular biology (mRNAs and non-coding RNAs), and for ex-vivo imaging.
MArco Piola
scientific advisor
is the R&D Manager at Qura S.r.L. and in 2013 he obtained a PhD in Biomedical Engineering. He is expert in the design, development and prototyping of mechanical components for cell culture systems, as well as industrialization processes.
HOW IT
STARTED
TToP’s idea was conceived in 2018, during the master thesis project of Lorenzo Coppadoro done at Politecnico di Milano. The project was driven by the need of overcoming conventional systems’ limitations for cell and tissue in vitro.
Initially the platform was developed and technically validated at Politecnico di Milano under the supervision of proff. Fiore and Soncini and Dr. Piola (PhD), and then integrated in standard laboratory procedures at Ospedale San Raffaele. Thanks to the collaboration with Dr. Chiara Foglieni and Maria Lombardi, TToP’s platform has been biologically validated in different relevant case studies such as cell cultures, tissue cultures. Today, TToP’s focus is to develop advanced modules that can recreate specific physiological / pathological conditions with an automated control. To date, the platform is at a TRL 4 thanks to a complete technical and biological validation.
The technology has been protected with a national patent (patent pending) and with the PCT extension.
Moreover, we are in contact with an Italian pharmaceutical company, to develop a personalized in vitro model and with a Venture Capital fund, that is sustaining the startup with a Proof-of-Concept pre-Seed. At the same time, we have started important scientific collaborations with national and international research groups, aiming at validating the platform in different context of use and demonstrating its performances to the scientific community.
open
careers
WE ARE LOOKING FOR NEW PROFESSIONALS to JOIN OUR TEAM.
Senior scientist (Biotech):
Junior scientist (bioeng)
Junior scientist (biologist)
Senior scientist (Biotech):
We are in need of a person with a PhD, who is able to manage a lab bioing, therefore planning of activities, management of resources, preparation and delivery of deliverables and purchasing management.
Junior scientist (bioeng)
We are in need of a person who has a PhD in the field of bioengineering, preferably who knows the world of unconventional culture systems. More operational figure who carries on R&D strands.
Junior scientist (biologist)
We are in need of a person who has experience in the field of cell cultures.